Bile acid and nonalcoholic steatohepatitis: Molecular insights and therapeutic targets
Background: Nonalcoholic steatohepatitis (NASH) has been the second most common cause of liver transplantation in the United States.To date, NASH pathogenesis has not been fully elucidated but is multifactorial, involving insulin resistance, obesity, metabolic disorders, diet, dysbiosis, and gene polymorphism.An effective and approved therapy for N